Volume 25, 2011

Table of Contents

Volume 25, Issue 4, 2011

Special Issue: Novel Pharmaconeurogenetic Approaches Arising from Progress in Translational Genetics

Special Issue Articles


Preface to the Special Issue “Novel Pharmaconeurogenetic Approaches Arising from Progress in Translational Genetics”

Guest Editors John J. Renger & Jonathan T. Kern

Original Research Articles

The Selective Phosphodiesterase 9 (PDE9) Inhibitor PF-04447943 Attenuates a Scopolamine-Induced Deficit in a Novel Rodent Attention Task

Joshua D. Vardigan, Antonella Converso, Pete H. Hutson, & Jason M. Uslaner

Targeting Post-translational Modifications on Tau as a Therapeutic Strategy for Alzheimer's Disease

Jacob Newman Marcus, & Joel Schachter

A Point Mutation at F1737 of the Human Nav1.7 Sodium Channel Decreases Inhibition by Local Anesthetics

Jacqueline Panigel & Sean Peter Cook

Leucine-Rich Repeat Kinase 2 (LRRK2) Cellular Biology: A Review of Recent Advances in Identifying Physiological Substrates and Cellular Functions

Robert E. Drolet, John M. Sanders, & Jonathan T. Kern

Characterization of an mGluR2/3 Negative Allosteric Modulator in Rodent Models of Depression

Brice Campo, Mikhail Kalinichev, Nathalie Lambeng, M. El Yacoubi, Isabelle Royer-Urios, Manfred Schneider, Coline Legrand, Delphine Parron, Francoise Girard, Abdelhak Bessif, Sonia Poli, Jean-Marie Vaugeois, Emmanuel Le Poul, & Sylvain Celanire

Pharmacological Validation of Candidate Causal Sleep Genes Identified in an N2 Cross

Joseph I. Brunner, Anthony L. Gotter, Joshua Millstein, Susan Garson, Jacquelyn Binns, Steven V. Fox, Alan T. Savitz, He S. Yang, Karrie Fitzpatrick, Lili Zhou, Joseph R. Owens, Andrea L. Webber, Martha H. Vitaterna, Andrew Kasarskis, Victor N. Uebele, Fred Turek, John J. Renger, & Christopher J. Winrow

Phenotypic Variability in a Large Czech Family with a Dynamin 2–Associated Charcot-Marie-Tooth Neuropathy

J. Haberlová, R. Mazanec, P. Ridzoň, L. Baránková, G. Nürnberg, P. Nürnberg, H. Sticht, K. Huehne, P. Seeman, & B. Rautenstrauss

High Frequency of Mutations in the PIK3CA Gene Helical and Kinase Coding Regions in a Group of Iranian Patients with High-Grade Glioblastomas: Five Novel Mutations

Pupak Derakhshandeh-Peykar, Jalil Alivi, Arash Hosseinnejad, Bernd Rautenstrauss, Reza Ebrahimzadeh Vesal, & Afsoon Doriani

Genes Involved in Cerebrospinal Fluid Production as Candidate Genes for Late-Onset Alzheimer's Disease: A Hypothesis

Peter Wostyn, Debby van Dam, Kurt Audenaert, & Peter Paul de Deyn

Overexpression of Human MRP1 in Neurons causes resistance to Antiepileptic Drugs in Drosophila Seizure Mutants

Guan-Shui Bao, Wen-An Wang, Tian-Zhe Wang, Jian-Kang Huang, Hua He, Zhenguo Liu, & Fu-De Huang

Volume 25, Issue 3, 2011

Includes Tribute to Howard Nash

Tributes to Howard Nash

“Entitlement, No! Gratitude, Yes!”

K. S. Krishnan & Chun-Fang Wu

Beginnings of Neurogenetics in the Nash Laboratory

K. S. Krishnan

Challenging the Prevailing Hypothesis

Daniel B. Campbell

What I learned from Howard about Using Genetics to Study the Anesthesia Response in Flies

Joseph Campbell

Copy Number-Based Genetic Screen to Uncover Nocel Anesthetic Targets

Debasmita Sandstrom

Reminiscences as Howard's Student, Collaborator, and Colleague

Ravi Allada

Original Research Articles

Workshop Report: European Workshop on Ataxia-Telangiectasia, Frankfurt, 2011

Stefan Zielen & Ralf Schubert

Contribution of 1425G/A Polymorphism in Protein Kinase C-Eta (PRKCH) Gene and Brain White Matter Lesions to the Risk of Sudden Sensorineural Hearing Loss in a Japanese Nested Case-Control Study

Yasue Uchida, Saiko Sugiura, Tsutomu Nakashima, Fujiko Ando, & Hiroshi Shimokata

Development of Patient-Specific Neurons in Schizophrenia Using Induced Pluripotent Stem Cells

Erika Pedrosa, Vladislav Sandler, Abhishek Shah, Reed Carroll, Chanjung Chang, Shira Rockowitz, Xingyi Guo, Deyou Zheng, & Herbert M. Lachman

Extracellular Protons Reduce Quantal Content and Prolong Synaptic Currents at the Drosophila Larval Neuromuscular Junction

David J. Sandstrom


Volume 25, Issue 1-2, 2011

Short Communications

Anatomical Characterization of Thermosensory AC Neurons in the Adult Drosophila Brain

Hsiang-Wen Shih & Ann-Shyn Chiang

HFE H63D, C282Y and AGTR1 A1166C Polymorphisms and Brain White Matter Lesions in the Aging Brain

Ola H. Gebril, Janine Kirby, George Savva, Carol Brayne, & Paul G. Ince

Deletion Analysis of SMN1 Exon 7 Alone May Be Necessary and Sufficient for the Diagnosis of Spinal Muscular Atrophy

Teguh Haryo Sasongko, Gunadi, Bin Alwi Zilfalil, & ZAMH Zabidi-Hussin

The Serotonin Transporter Expression in Drosophila melanogaster

Thomas Giang, Steffen Rauchfuss, Maite Ogueta, & Henrike Scholz

Association Analysis of TPH2, 5-HT2A, and 5-HT6 With Executive Function in a Young Chinese Han Population

Pingyuan Gong, Fuchang Zhang, Wanhu Ge, Xu Lei, Wanyu Chi, Kejin Zhang, Anyun Zheng, & Xiaocai Gao

Stress Resistance Conferred by Neuronal Expression of Dominant-Negative Rac in Adult Drosophila melanogaster

Yichun Shuai, Yisi Zhang, Liwen Gao, & Yi Zhong

Machine Learning Methods Predict Locomotor Response to MK-801 in Mouse Models of Down Syndrome

Cao D. Nguyen, Alberto C. S. Costa, Krzysztof J. Cios, & Katheleen J. Gardiner

Promotion of Sleep by Suvorexant—A Novel Dual Orexin Receptor Antagonist

Christopher J. Winrow, Anthony L. Gotter, Christopher D. Cox, Scott M. Doran, Pamela L. Tannenbaum, Michael J. Breslin, Susan L. Garson, Steven V. Fox, Charles M. Harrell, Joanne Stevens, Duane R. Reiss, Donghui Cui, Paul J. Coleman, & John J. Renger



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